Interaction Mechanism between Antibiotics and Humic Acid by UV-Vis Spectrometry

Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats.

The Ministry of Health and Welfare, Japan banned coadministration of carbapenems, such as panipenem/betamipron (PAPM), meropenem (MEPM), and valproic acid (VPA) because clinical reports have indicated that the coadministration caused seizures in epileptic patients due to lowered plasma levels of VPA. In this study, we have clarified the mechanism of the drug-drug interaction using PAPM, MEPM, a...

Mechanism of Drug Interaction between Valproic Acid and Carbapenem Antibiotics via Acylpeptide Hydrolase

Chlorophylls and Carotenoids: Measurement and Characterization by UV-VIS Spectroscopy

The quantitative determination of chlorophyll (Chl) a, Chl b, and carotenoids in a wholepigment extract of green plant tissue by UVVIS spectroscopy is complicated by the choice of sample, solvent system, and spectrophotometer used. The various plant pigments absorb light in overlapping spectral regions, depending on the system selected. This unit discusses methods used to account for such overl...

Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid.

Induction of urokinase plasminogen activator (uPA) by retinoic acid (RA) is the initial event preceding certain subsequent biological changes in vascular endothelial cells. We investigated the molecular mechanism by which RA stimulates the expression of uPA, which lacks a canonical RA receptor (RAR)-responsive element, in bovine and human aortic endothelial cells. Upon stimulation with RA, mRNA...

SAOZ UV-Vis remote measurements

Long series of ozone profiles from 6 to 28 km at the Southern Tropics have been obtained from solar occultation measurements at twilight using a SAOZ spectrometer borne by long duration balloons. Two flights have been performed from Bauru in Brazil both in the summer, in February and March 2001 and 2003, from where the balloons 5 are moving westward at almost constant latitude (20 • ±5 • S). Th...